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There is a general believe that bitter kola is an aphrodisiac agent, thus men consume it to enhance their libido. This study is aimed at assessing the effect of bitter kola on male sex hormones. Twenty-four adult male Wistar rats were randomly divided into four groups of six each after seven days acclimatization period. Animals in group 1 were administered normal saline solution while those in groups 2, 3 and 4 were administered 100, 200 and 400 mg/kg body weight of bitter kola extracts respectively for twenty-eight days. Administration was done 12 hourly via oral route. At the end of the administration period, the rats were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected via cardiac puncture. Serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone were determined using enzyme-linked immunosorbent assay (ELISA). A dose-dependent reduction was observed in serum levels of LH and testosterone in animals exposed to bitter kola extract when compared with those in animals in the control group at P<0.05. However, bitter kola administration had no significant effect on serum level of FSH at all doses investigated. This result showed that bitter kola possesses the propensity to reduce fertility in male Wistar rats.

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Augustine I. Airaodion, John A. Ekenjoku, Ada C. Ngwogu, Kenneth O. Ngwogu, Anthony U. Megwas, & Akaninyene U. Ime. (2020). Antaphrodisiac Potential of Bitter Kola (Garcinia kola) Seeds in Male Wistar Rats. International Journal of Bio-Science and Bio-Technology, 12(3), 36-43. Retrieved from