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Abstract
HIV is a pandemic which has spread across the world. Millions of people suffer from HIV and lose their lives because of this deadly virus. Computational tools have already helped in the discovery of HIV-1 integrase inhibitors, the best example in this regards is Ritonavir. It is a highly active anti-retro viral drug which was discovered with the help of CADD. Bioinformatics is the science of managing and analyzing huge amount of biological data with the help of advanced computing tools and software programmes. Biological databases provides potential and useful drug targets associated with the HIV drug resistance. HIV drugs such as Doravirine, rilpivirine, nevirapine, atazanavir, lopinavir etc have shown resistance.