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Abstract
Hexavalent chromium compounds are genotoxic carcinogens; chronic inhalation of hexavalent
chromium compounds increases the risk of lung cancer. The mechanism of genatoxicity relies on
pentavalent and trivalent chromium. The damage is caused by hydroxyl radicals, produced during
reoxidation of pentavalent chromium by hydrogen peroxide molecules present in the cells. The sub
chronic and chronic oral RFD for hexavalent chromium are 0.02 and 0.005mg/kg/day (U.S.E.P.A. 1990).
Based on adequate proof for humans and animals hexavalent chromium is placed in the EPA weight of
evidence classification a human carcinogen.