Synthesis, Characterization and Anti Tuberculosis Activity of Substituted Indole-3-Carboxaldehyde Thiosemicarbazonesand Their Ni(II) Complexes

Abstract

Nickel acetatereacted withtwo moles of substituted indole-3-carboxaldehydethiosemicarbazones (HIntsc, H¹L; HIntscN¹Me, H²L and HIntscN¹Ph, H³L) to form complexes of stiochiometry, [Ni(L)₂] (¹L, 1; ²L, 2; ³L, 3). All the complexes (1-3) have been characterized using elemental analysis, IR,¹HNMR spectroscopy. Spectroscopic data is suggesting binding of ligand to nickel center through azomethine nitrogen and thiolate and formation of square planar geometry in 1-3. Ligands and their complexes have been tested for anti-TB activity using Micro Plate Alamar Blue assaymethod. Ligands (H¹L and H²L) are active at MIC 12.5 µg/ml and H³L at MIC 25 µg/ml. Complexes 1-3showed less activity than their corresponding ligands.