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Abstract

From primeval time, topical medicine were applied on skin. In recent time, topical formulations for pharmaceutical delivery are becoming increasingly popular. Research scientist has emphasized more on dermatopharmacokinetic along with formulation component, as the impact of the formulation ingredient will affect the release kinetics of drugs. Stratum corneum, which act as barrier for dermatopharmacokinetic of the drug, has barrier need to be considered before formulating any drug formulation for topical skin. Formulation play important role in skin permeation of drugs, nanocargo delivery system has shown better permeation profiles. Different dermatopharmacokinetic methodology have been used to eradicate the animal use and implement the 3R.

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