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Abstract
Enone moiety (-C=C-CO-) is an important functionality of bioactive compounds having diverse types of biological activities. It is constructed by attaching a double bond (ene) in conjugation to a keto group (one) asan a,b-unsaturated carbonyl group via different types of condensation reactions. This moiety provides two electrophilic sites as b-C and C=O for nucleophiles thus undergoes different types of chemical reactions. The electrophilicity of enone moiety has been recognised as an important characteristic for interactions of small molecules (ligands) with target protein to modified biological response for anticancer, antidiabetic, antibacterial, antifungal, antimalarial, antiviral etc. Here, we reviewed interactions of enone moiety with different amino acid residues of targets proteins.