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Abstract
The term “Endophyte”, introduced by de Bary (1866) (6). Endophytic fungi have been known as
a potential source of bioactive metabolite (4). endophytes are live internal tissues of host plants.
fungal endophytes are beneficial for plants by promoting plant growth (3). endophytic fungi
producing secondary metabolite substances that can be used by inhibit the growth of pathogens.
There is a complex relationship between endophytic fungi and their host plants. Some these
substances proved useful for novel drug discovery (5). These secondary metabolites showed
antifungal and antibacterial activity against plant pathogens. endophytic fungi play an important
role of natural ecosystems. The recently found that endophytic fungi have the unique substances
represent a huge diversity.