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The study aimed to assess the effect of drying (freeze, tray and sun) and solvent (methanol, ethanol, water, acetone and hexane) on the antibacterial activity of extract from pomegranate by products. Antibacterial activity against six strains of pathogen (S. thermophilus P. aeruginosa, E. coli, Bifidobacteria, E. faecalis and L. acidophilus) were determined. All pomegranate peel extracts demonstrated selective antimicrobial activity against all pathogenic bacteria. The extraction of freeze drying powder in methanol showed maximum inhibitory concentration at 20, 25, 30 and 35 μl volumes followed by ethanol, water and acetone. Extraction in hexane solvent did not showed inhibitory concentration against selected pathogenic strains.

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