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Kerala state in India has got the unique distinction of being the state with one of the highest literacy rates in the country. Also, Kerala has got a remarkable track record of migration of skilled professionals to other parts of India and also elsewhere in the world. The case of trained nurses is no exception in this regard. Over the years there has been a steady rise in the migration of nurses from Kerala to other parts of the world. In fact, nurses from Kerala constitute vast majority of those who migrate abroad from the whole of India. In the above backdrop, this paper makes a closer look into the migration phenomenon of nurses from Kerala, the political economy of migration including the major destinations of nurses migrating from Kerala, the implications of such migrations on Kerala economy and suggests suitable strategies.