Main Article Content
Abstract
Neurodegeneration is the major problem among the old aged people and is of major concern as it is increasing the social burden. The second major neurodegenerative disease of major concern is Parkinson’s disease. One of the major motor symptoms of Parkinson’s disease is locomotory incompetence. Here in this study we are using different concentration of rotenone for the generation of the locomotory disability in the wild type Drosophila melanogaster (Oregon R+) strain. With the different concentration of the rotenone we found that the flies are showing the locomotory disability along with the death of flies during the treatment period. In two higher concentrations, 5 ppm and 0.5 ppm of rotenone, the fly dies after 24 hours and 48 hours of treatment respectively thus leading to early mortality.