Main Article Content
Abstract
Auto-inflammatory diseases is a group of clinical manifestation that share common distribution pattern with auto-immune disorders, however differs in symptoms such as recurrent episodes of inflammation. The pathophysiology of auto-inflammatory diseases involves dysfunction of innate immune system. The various examples of auto-inflammatory diseases includes crohn disease, behcet disease, schnitzel syndrome, systemic juvenile idiopathic arthritis, familial Mediterranean fever, TNF receptor associated periodic syndrome, ankylosing spondylitis, stomatitis recurrent aphthous ulcer, psoriatic arthritis, gout, sarcoidosis. Conventional treatment approach of auto-inflammatory diseases involves immunomodulators (cyclosporine, mercaptopurine, methotrexate, azathrioprine); corticosteroids ( prednisone, budesonide, methyl prednisone); aminosalicylates (sulfasalazine, mesalamine); biologics (infliximab, certolizumab, adalimumab) and NSAIDS (acetaminophen and ibuprofen) are used. All these drugs are associated with one or more side effects. As per the study conducted by the World Health Organization about 80% of world’s population relies on traditional medicine. Various plants have been used traditionally in management of auto-inflammatory diseases. Some of the important natural compounds reported to be used in treatment of auto-inflammatory diseases includes anthraquinone (Aloe vera, Rhamnus cathartica), curcuminoids (Curcuma longa), flavonoids (Chrysanthemum indicum, Colocasia antiquorum, Momordica charantia), volatile oil (Olchicum autumnale, Oenothera biennis, Borago officinalis, Allium cepa), polyphenols (Punica granatum, Vitis venifera). Although a number of herbal medicines are recommended for auto-inflammatory diseases, but further research is required to investigate their safety, efficacy, and potential drug interactions.