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Abstract
For a long time, bacteria were considered as self-directed unicellular organisms which shows the collective behaviour but up to lesser extent. However, we currently value that bacterial cells are actually communicative among themselves. This communication or coordination between bacterial population via signal molecules known as autoinducers or pheromones that diffuse in and out of bacterial cells. As the bacterial population increases the concentration of these signal molecules increases and the expressions of virulence factors are activated by this quorum sensing process. In Pseudomonas aeruginosa, quorum sensing controls many of these expressions of virulence factors. This study focused on the inhibition of these target proteins, so that a new series of molecules which can be used in the development of potent Quorum based anti-virulence therapeutics for targeting infections caused by Pseudomonas aeruginosa.