Main Article Content
Abstract
The most preferred and convenient route is an oral route for the delivery of a drug. The oral delivery of drugs is convenient but there is a partial release of drug due to the lesser residence time. To overcome this problem, a new approach came into light i.e. gastro retentive drug delivery system which includes raft formation. Raft formation is a novel approach for the delivery of oral dosage form. It is a liquid dosage form and has a density lesser than gastric content. So, remains floating over the gastric content. And once it gets interacted with gastric content, it changes to gel form. It is advantageous as it is patient compliance and is effective for an extended time period as it delivery of the drug from the dosage form is for more time. As the drug floats for a long time over the gastric content, it automatically leads to an increase in the local action of the drug and there is no need for frequent dosing. The conversion of solution to gel state is cation dependent or temperature-dependent. Various types of polymers which can be used in raft formation includes different approaches for gelation.