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Abstract
Drug repositioning is a pharmaceutical product technology flow that offers benefits to drug manufacturers along with patient-safer medicines. Several medications were repositioned effectively for targeting different indications. The pharmaceutical re-profiling is done with the main objective to establish strategies by using approved drugs and rejected drug candidates in the diagnosis of new diseases.Drug repositioning includes safety and adverse effects evidence from clinical trials that are already available and becoming increasingly attractive as it requires the use of less-risk substances such as already approved drugs, marketed products, discontinued drugs, shelved, and trial drugs with significantly lower average processing cost. There are many benefits of this strategy which include the shortened timeframe of drug development, best chances of completing Phase II or Phase III clinical trials, efficient design of dosage form and, of course, it will add value for products belonging to a business or laboratory inventory. Natural drug products are in use from ancient times which are promising candidates to be repurposed for curing diseases. In this review report, we presented an overview of the repurposing of herbal drug products including the process of current scenario of drug discovery and the opportunities and challenges which occur during the re-profiling of a natural drug product. It also summarises the subject of those herbal drug products on which drug repurposing is already done.