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Abstract

RS)- Atenolol is a beta blocker and is marketed as racemic mixture. Indirect enantioseparation of (RS)- Atenolol was done by using (S)- Ibuprofen as Chiral Derivatizing reagent. Diastereomers of atenolol were prepared. Further Thin layer chromatography was done for enantioseparation. The solvent system MeCN-CH2Cl2-MeOH-H2O, in different ratiowere performed.

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