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Abstract
Ketorolac tromethamine is a chiral drug which is marketed in its racemic form but because of the pharmacological effects due to molecule’s chirality, one of the enantiomer (i.e. R form) is more potent and other shows different activities. The separation of ketorolac enantiomers were performed by using pure Montair 10mg as chiral derivatizing reagent and its purification was checked by using UV, IR and TLC with mixture of water/ethylacetate/n-hexane as mobile phase. Reaction of R-Montair 10mg with racemic ketorolac leads to the formation of diastereomers. Resolution of enantiomers occurs due to their different activities as diastereomers and their identification was done by using TLC with mixture of methanol, dichloromethane, chloroform, water in different ratio.