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The Bedaquiline, Delamanid and Pretomanid are the anti-tuberculosis molecules approved in the last five years. The prediction and analysis of physico-chemical properties and brain access and gastrointestinal absorption properties of these molecules have been carried out using Swiss ADME, a free online software tool. From the prediction of these properties, the parameters need to be considered for designing the new chemical entities library has been discussed. These research findings will pave the way for the medicinal chemists to understand and rationalize the properties in design and development of the new chemical entities with quinolone and bicyclic 4-nitroimidazoles.

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